USPTO Patents Application 10054429

1/11

FIG. 1B

2/11

FIG. 1C

3/11

FIG. ID

4/11

FIG. 2B

TEMPERATURE. "C

5/11

ss=s:

~5? =

3 "S-

13+17

TEMPERATURE, °C

FIG. 3

6/11

1

=3=

+

o

CM
+

CM

CD

to

L_ O

m
o

LO

CO

CM

O

to

LO

L. o
_ to

LO

o

LO
LO

O

LO

LO

O .J

^! x

O LU

c
E

LLJ

LO f

t

ft •
ft t

*

<

CD

LL

* I

!

#

7/11

OLIGO. #
EXPT. #

17

13

13+17

i r

2 3
i r

TIME.min 0 1 5 15 0 1 5 15 0 1 5 15 0^ 1 5 15

FIG. 4B

8/11

9/11

o
o

o

00

o

CO

o

o

NOIliaiHNI %

10/11

□

=1

O

o
o

— r

o

CO

CD

+
CM

+
CD

O
CD

O

O
CN

,e ,9

3 9

CM
+

D
3
0

0
3
3

I s -

o

LL

C 31393V333 13 131 3133 113 c

D D
D 0
D 3
3 3

- ig 31303¥333 13 131 3133 113,2

,C,9

0 3
3 9
3 9

. g 31393V333 13 131 3133 113 £

,e,9

9 3
3 9
3 9

. g 31393V333 VI3 131 3133 11 g

CO
LU

q

(-
o

LU
I

o

D
Z

o

CD
_i

o

-g3I393Y333-YI3 131 3133 Jig

3I393V333 ¥13 131 3133 11

• ~3I3I393V333YI3 131 3133 1131 c

.3 it

NOIliaiHNI %

11/11

CJ

&H

o

I

o

uuu O CO
EjOO cj Co
E-»

o

E-<

CJ
Eh
CJ
CJ

E '
Eh
CJ

CO

o

CJ

§

CJCJ CJ OOCJ CO

hOO uuo Co
o

Eh

cj

E— 1

cj

CJ
CJ

Eh
Eh
CJ

CO

LO

CJ
Eh
CJ

o

CJ

<

CJ

CJ CJCJ CJ CJ CJ O CJ CO

HOOU UOUOLO
CJ

Eh
CJ
Eh

CJ

B

CJ

Eh
Eh
CJ

CO

OLIGONUCLEOTIDE COMBINTATION

FIG. 8